ABSTRACT
Objective To investigate the clinical efficacy of laparoscopic surgery combined with chemotherapy drugs in patients with cervical cancer. Methods 60 patients with cervical cancer treated in our hospital from January 2015 to July 2016 were randomly divided into two groups:control group (n=30) and observation group (n=30). The two groups were treated with chemotherapy, the control group was treated with open surgery, the observation group was treated with laparoscopic surgery, the clinical efficacy of the two groups were compared. Results The operation time of the observation group was longer than that of the control group (P<0.05). The amount of bleeding, the exhaust time and the length of stay in the observation group were shorter than those in the control group (P<0.05). Conclusion Laparoscopic surgery for cervical cancer patients is effective, less trauma, and is conducive to postoperative recovery. It is worthy of popularization and application.
ABSTRACT
Objective To study the effect of combining loop electrosurgical excision procedure (LEEP) and recombinant human interferon α2b (rhIFNα-2b) suppository in treatment of cervical intraepithelial neoplasia (CIN).Methods Prospective,random and control study was conducted in 82 patients with CINⅠ-CINⅢ.Before canting out LEEP to these patients,all women were performed HPV DNA detection by the method of Hybri Max.Among these patients,41 patients were assigned to the studying group,in which the patients were given rhIFNα-2b suppository for three courses of treatment after LEEP.The other 41 patients who carried out LEEP simply were assigned to the control group.Liquid-based ThinPrep cytology test (TCT) and HPV DNA were examined in the sixth and twelfth month after treatment.Results In the studying group,the cure rate was 90.2％ when LEEP ended six months,and the cure rate was 100.0％ when LEEP ended twelve months.In the control group,the cure rate was 43.9％ when LEEP ended six months,and the cure rate was 61.0％ when LEEP ended twelve months.In the sixth and twelfth month after LEEP,the difference was significant when we compared the cure rate between the two groups (x2 =19.93,19.89,all P ＜ 0.05).Conclusion The clinical effect of combining LEEP and rhIFNα-2b suppository is better than LEEP in treatment of CIN.The method can remove or destroy the cervical lesions effectively and inhibit HPV replication and spread of HPV infection.